Clemson vs LSU Prop Picks for College Football Week 1

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It’s the Game of the Week, and we are getting absolutely spoiled in Week 1, with Clemson and No. 11 LSU facing off Saturday night.

Without wasting anymore time, here are my Clemson vs. LSU prop picks, including two LSU Tigers to find the end zone.

Before you start scrolling through all the filth, be sure to check out all the plays our team is on this weekend, along with my college football picks for Week 1.

Best Clemson vs LSU props

Prop pick #1: Christian Vizzina Over 1.5 Interceptions (40%)

This writer will be leaning heavily into the low confidence level surrounding Clemson Tigers starting quarterback Christopher Vizzina, who will make his second career start Saturday.

Head coach Dabo Swinney has alluded to Vizzina being on a short leash. If the former four-star recruit does not make a significant impact early, we could see freshman Tait Reynolds sooner than later get his chance to take over as the starter.

If Vizzina does not come out hot and makes a few mistakes early, he could find himself on the bench in the second half. That is why we are leaning into him getting picked off twice in this matchup.

If the pressure is this heavy right out of the gate, we will see how good this kid really is against an LSU Tigers defense that returned a bunch of talent while adding starters from other SEC defenses.

Take down to 40%.

Prop pick #2: Jayce Brown Anytime Touchdown (32%)

Former Kansas State standout Jayce Brown has generated plenty of hype since transferring to LSU. The senior receiver caught 41 passes for 712 yards and 5 touchdowns last season for the Wildcats, averaging 17.4 yards per catch.

The 2025 All-Big 12 receiver has reportedly emerged as one of Sam Leavitt’s top targets in practice. When in doubt, trust your favorite pair of hands. Brown should provide a viable deep threat in this matchup.

Look for Leavitt to connect with Brown downfield.

Take this down to 40%.

Trey'Dez Green Anytime Touchdown (43%)

Another target reportedly among Leavitt’s favorites is LSU’s all-time touchdown leader among tight ends, Trey’Dez Green. He is arguably the team’s best pass catcher and one of its most athletic players. Green should be Leavitt’s safety blanket and go-to target in the red zone. At 6-foot-7, 240 pounds, the tight end is a mismatch nightmare.

In 2025, Green caught 33 passes for 433 yards, averaging 13.1 yards per catch, while scoring 7 touchdowns.

Despite the price, Green should be heavy red zone target in this matchup, but do not take this price any lower.

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