Predicting Big 12 football scores in Week 2: Arizona-BYU features elite QB matchup

Predicting Big 12 football scores in Week 2: Arizona-BYU features elite QB matchup

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Predicting Big 12 football scores in Week 2: Arizona-BYU features elite QB matchup

There are some fascinating games featuring Big 12 teams in Week 2 of the college football slate. The Oklahoma State Cowboys could either prove last week was a mirage, or they aren’t as good as expected.

There will also be a great game featuring two of the Big 12’s top QBs this weekend when BYU and Arizona face off against one another.

Here’s how all the Big 12 games might turn out.

MORE: Predicting ACC football scores in Week 2: Georgia Tech has pivotal game vs. Tennessee

No. 6 Oregon vs. Oklahoma State

Oklahoma State quarterback Drew Mestemaker (17) warms up before a college football game between Oklahoma State (OSU) and Tulsa

Oklahoma State quarterback Drew Mestemaker (17) warms up before a college football game between Oklahoma State (OSU) and Tulsa at H. A. Chapman Stadium in Tulsa, Okla., on Saturday, Sept. 5, 2026. Credit: USA TODAY Network via Reuters Connect (Reuters)

Both Oregon and Oklahoma State had disappointing openers, but only one of the two teams got the win.

The Ducks played Boise State at home as a 24.5-point favorite, but the game went late into the fourth quarter before Oregon came away with a 34-27 win over the Broncos. Dante Moore played well enough, but the defense was disappointing.

As for Oklahoma State, the Eric Morris era got off to a poor start. The Cowboys lost to Tulsa, 24-10, and Drew Mestemaker threw two interceptions in the loss. He will have to play much better if Oklahoma State wants to pull off the upset.

Final score: Oregon 41, Oklahoma State 20

Arizona State vs. No. 10 Texas A&M

Arizona State quarterback Cutter Boley (8) warms up before their game against the Morgan State Bears at Mountain America Stadium

Arizona State quarterback Cutter Boley (8) warms up before their game against the Morgan State Bears at Mountain America Stadium in Tempe on Sept 5, 2026. Credit: USA TODAY Network via Reuters Connect (Reuters)

Both programs got off to roaring starts in Week 1, but neither played an FBS opponent. However, it was impressive that Kentucky transfer Cutter Boley threw for 387 yards and six TDs in Arizona State’s 70-7 win over Morgan State.

Texas A&M played up to its standard, as well. The Aggies’ hard-nosed defense forced a shutout against Missouri State, 51-0.

The Sun Devils are going to need a lot of the same out of Boley if they are going to upset the Aggies. But it’s hard to predict that.

Final score: Texas A&M 34, Arizona State 17

Arizona vs. No. 15 BYU

NCAA Football: Utah Tech at Brigham Young

Sep 5, 2026; Provo, Utah, USA; BYU Cougars quarterback Bear Bachmeier (47) dives for a touchdown against Utah Tech Trailblazers defensive lineman Fasitootai Sagapolu (3) during the second quarter at LaVell Edwards Stadium. Mandatory Credit: Rob Gray-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)

We’ve got two of the best QBs in the Big 12 going at one another in this game. Noah Fifita threw for 279 yards and two TDs in the Wildcats’ 35-7 win over Northern Arizona in Week 1. And BYU’s Bear Bachmeier tossed for 198 yards and three TDs in its 63-7 win over Utah Tech.

Fifita is talented, and maybe the best in the Big 12, but how much talent does he have around him? This game is going to answer that, especially going up against a very good Cougars’ defense. This game will likely come down to the final possession.

Final score: BYU 27, Arizona 21

The rest of the games will be quick-hitter style

  • No. 23 Missouri 31, Kansas 17
  • Kansas State 27, Washington State 10
  • West Virginia 34, UT Martin 9
  • Colorado 48, Weber State 13
  • Pitt 31, UCF 24
  • No. 22 Houston 41, Southern 7
  • Cincinnati 45, Western Carolina 10
  • No. 13 Texas Tech 38, Oregon State 14
  • No. 21 Iowa 24, Iowa State 7
  • TCU 41, Grambling 13
  • Baylor 38, Prairie View A&M 10
  • No. 20 Utah 31, Arkansas 17

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