College Football Week 11 Expert Picks for the 16 Biggest Games

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College Football Week 11 Expert Picks for the 16 Biggest Games

Like last week, when Penn State vs Ohio State was supposed to be a giant deal, this weekend is a bit of a disappointment, too.

This was supposed to be the week of weeks, with LSU and Alabama taking center stage, and Indiana at Penn State a rematch of playoff teams from last year.

But last week was certainly fun – especially if you had access to ESPN and ABC – and this will be a big week, too, as more pieces come together with games like Oregon at Iowa, Texas A&M and Missouri, and yeah, LSU at Alabama, too.

The CFN Experts pick those three, and UTSA at USF, Northwestern at USC, Tulane at Memphis, Indiana at Penn State, Georgia at Mississippi State, BYU at Texas Tech, Ohio State at Purdue, Syracuse at Miami, Wake Forest at Virginia, Florida State at Clemson, Navy at Notre Dame, Nebraska at UCLA, and San Diego State at Hawaii.

Expert Predictions for Oregon at Iowa and All the Top Week 11 Matchups

Oct 25, 2025; Iowa City, Iowa, USA; Iowa Hawkeyes quarterback Mark Gronowski (11) warms up before the game against the Minnesota Golden Gophers at Kinnick Stadium. © Jeffrey Becker-Imagn Images

UTSA at USF

Game Time: 7:30 PM ET
TV: ESPN
Consensus Line: USF -13.5
– Game Preview & Prediction Coming

Big Game Ben: USF*
E: USF*
Nathan Erbach: USF
Pete Fiutak: USF
John Kennedy: USF
Jackson Langendorf: USF*
Andrew Margolick: USF*
Jake Margolick: USF*
Doug Millen: USF
Johnny Rosenstein: USF*
Joshua Schulman: USF*
Nick Shepkowski: USF*
Clucko the Chicken: UTSA
CONSENSUS PICK: USF*

Northwestern at USC

Game Time: 9:00 PM ET
TV: FOX
Consensus Line: USC -14.5
– Game Preview & Prediction

Big Game Ben: USC*
E: USC
Nathan Erbach: USC
Pete Fiutak: USC
John Kennedy: USC
Jackson Langendorf: USC
Andrew Margolick: USC
Jake Margolick: USC*
Doug Millen: USC*
Johnny Rosenstein: USC
Joshua Schulman: USC
Nick Shepkowski: USC*
Clucko the Chicken: Northwestern
CONSENSUS PICK: USC

Tulane at Memphis

Game Time: 9:00 PM ET
TV: ESPN
Consensus Line: Memphis -4.5
– Game Preview & Prediction Coming

Big Game Ben: Memphis
E: Memphis
Nathan Erbach: Tulane
Pete Fiutak: Memphis*
John Kennedy: Memphis
Jackson Langendorf: Memphis
Andrew Margolick: Memphis
Jake Margolick: Tulane
Doug Millen: Memphis
Johnny Rosenstein: Memphis
Joshua Schulman: Memphis
Nick Shepkowski: Memphis*
Clucko the Chicken: Memphis
CONSENSUS PICK: Memphis

Indiana at Penn State

Game Time: 12:00 PM ET
TV: FOX
Consensus Line: Indiana -14.5
– Game Preview & Prediction

Big Game Ben: Indiana
E: Indiana
Nathan Erbach: Indiana*
Pete Fiutak: Indiana
John Kennedy: Indiana
Jackson Langendorf: Indiana*
Andrew Margolick: Indiana
Jake Margolick: Indiana
Doug Millen: Indiana
Johnny Rosenstein: Indiana*
Joshua Schulman: Indiana
Nick Shepkowski: Indiana
Clucko the Chicken: Penn State
CONSENSUS PICK: Indiana

Georgia at Mississippi State

Game Time: 12:00 PM ET
TV: ESPN
Consensus Line: Georgia -8.5
– Game Preview & Prediction Coming

Big Game Ben: Georgia
E: Georgia
Nathan Erbach: Georgia
Pete Fiutak: Georgia
John Kennedy: Georgia
Jackson Langendorf: Georgia
Andrew Margolick: Georgia
Jake Margolick: Georgia
Doug Millen: Georgia*
Johnny Rosenstein: Georgia
Joshua Schulman: Georgia*
Nick Shepkowski: Georgia*
Clucko the Chicken: Mississippi State
CONSENSUS PICK: Georgia

BYU at Texas Tech

Game Time: 12:00 PM ET
TV: ABC
Consensus Line: Miami -28.5
– Game Preview & Prediction Coming

Big Game Ben: Texas Tech*
E: Texas Tech*
Nathan Erbach: Texas Tech*
Pete Fiutak: Texas Tech
John Kennedy: Texas Tech*
Jackson Langendorf: Texas Tech*
Andrew Margolick: Texas Tech*
Jake Margolick: Texas Tech*
Doug Millen: Texas Tech*
Johnny Rosenstein: Texas Tech*
Joshua Schulman: Texas Tech*
Nick Shepkowski: Texas Tech*
Clucko the Chicken: Texas Tech
CONSENSUS PICK: Texas Tech*

Oct 18, 2025; Evanston, Illinois, USA; Purdue Boilermakers head coach Barry Odom takes the field with his team in a game against the Northwestern Wildcats at Northwestern Medicine Field at Martin Stadium. © David Banks-Imagn Images

Ohio State at Purdue

Game Time: 12:00 PM ET
TV: BTN
Consensus Line: Ohio State -29.5
– Game Preview & Prediction

Big Game Ben: Ohio State
E: Ohio State
Nathan Erbach: Ohio State
Pete Fiutak: Ohio State
John Kennedy: Ohio State
Jackson Langendorf: Ohio State*
Andrew Margolick: Ohio State*
Jake Margolick: Ohio State*
Doug Millen: Ohio State*
Johnny Rosenstein: Ohio State
Joshua Schulman: Ohio State*
Nick Shepkowski: Ohio State
Clucko the Chicken: Ohio State
CONSENSUS PICK: Ohio State

Texas A&M at Missouri

Game Time: 3:30 PM ET
TV: ABC
Consensus Line: Texas A&M -6.5
– Game Preview & Prediction Coming

Big Game Ben: Texas A&M*
E: Texas A&M*
Nathan Erbach: Texas A&M
Pete Fiutak: Texas A&M
John Kennedy: Texas A&M
Jackson Langendorf: Texas A&M
Andrew Margolick: Texas A&M
Jake Margolick: Texas A&M
Doug Millen: Texas A&M
Johnny Rosenstein: Texas A&M
Joshua Schulman: Texas A&M*
Nick Shepkowski: Texas A&M
Clucko the Chicken: Missouri
CONSENSUS PICK: Texas A&M

Oregon at Iowa

Game Time: 3:30 PM ET
TV: CBS
Consensus Line: Oregon -6.5
– Game Preview & Prediction
Big Game Ben: Oregon
E: Oregon*
Nathan Erbach: Oregon
Pete Fiutak: Oregon
John Kennedy: Oregon
Jackson Langendorf: Oregon
Andrew Margolick: Iowa
Jake Margolick: Iowa
Doug Millen: Oregon*
Johnny Rosenstein: Oregon*
Joshua Schulman: Oregon*
Nick Shepkowski: Iowa
Clucko the Chicken: Iowa
CONSENSUS PICK: Oregon*

Syracuse at Miami

Game Time: 3:30 PM ET
TV: ESPN
Consensus Line: Miami -28.5
– Game Preview & Prediction Coming

Big Game Ben: Miami
E: Miami*
Nathan Erbach: Miami*
Pete Fiutak: Miami
John Kennedy: Miami *
Jackson Langendorf: Miami*
Andrew Margolick: Miami*
Jake Margolick: Miami*
Doug Millen: Miami
Johnny Rosenstein: Miami
Joshua Schulman: Miami
Nick Shepkowski: Miami*
Clucko the Chicken: Miami
CONSENSUS PICK: Miami*

Wake Forest at Virginia

Game Time: 7:00 PM ET
TV: ESPN
Consensus Line: Virginia -6.5
– Game Preview & Prediction Coming

Big Game Ben: Virginia
E: Virginia
Nathan Erbach: Virginia
Pete Fiutak: Virginia*
John Kennedy: Virginia
Jackson Langendorf: Virginia
Andrew Margolick: Virginia
Jake Margolick: Virginia
Doug Millen: Virginia
Johnny Rosenstein: Virginia*
Joshua Schulman: Virginia
Nick Shepkowski: Virginia
Clucko the Chicken: Wake Forest
CONSENSUS PICK: Virginia

Florida State at Clemson

Game Time: 7:00 PM ET
TV: ACC Network
Consensus Line: Clemson -2.5
– Game Preview & Prediction Coming

Big Game Ben:
E: Clemson
Nathan Erbach: Clemson
Pete Fiutak: Florida State
John Kennedy: Clemson
Jackson Langendorf: Florida State
Andrew Margolick: Florida State
Jake Margolick: Clemson
Doug Millen: Florida State
Johnny Rosenstein: Clemson
Joshua Schulman: Clemson
Nick Shepkowski: Clemson
Clucko the Chicken: Clemson
CONSENSUS PICK: Clemson

Navy at Notre Dame

Game Time: 7:30 PM ET
TV: NBC
Consensus Line: Notre Dame. -26.5
– Game Preview & Prediction Coming

Big Game Ben: Notre Dame
E: Notre Dame
Nathan Erbach: Notre Dame
Pete Fiutak: Notre Dame
John Kennedy: Notre Dame
Jackson Langendorf: Notre Dame*
Andrew Margolick: Notre Dame
Jake Margolick: Notre Dame
Doug Millen: Notre Dame*
Johnny Rosenstein: Notre Dame
Joshua Schulman: Notre Dame*
Nick Shepkowski: Notre Dame
Clucko the Chicken: Navy
CONSENSUS PICK: Notre Dame

LSU Tigers take on the South Carolina Gamecocks. October 11, 2025; Baton Rouge, Louisiana, USA; at Tiger Stadium.© SCOTT CLAUSE / USATODAY Network / USA TODAY NETWORK via Imagn Images

LSU at Alabama

Game Time: 7:30 PM ET
TV: ABC
Consensus Line: Alabama -10
– Game Preview & Prediction

Big Game Ben: Alabama
E: Alabama
Nathan Erbach: Alabama
Pete Fiutak: Alabama*
John Kennedy: Alabama
Jackson Langendorf: Alabama
Andrew Margolick: Alabama
Jake Margolick: Alabama
Doug Millen: Alabama
Johnny Rosenstein: Alabama
Joshua Schulman: Alabama
Nick Shepkowski: Alabama*
Clucko the Chicken: LSU
CONSENSUS PICK: Alabama

Nebraska at UCLA

Game Time: 9:00 PM ET
TV: FOX
Consensus Line: UCLA -1.5
– Game Preview & Prediction

Big Game Ben: Nebraska
E: UCLA
Nathan Erbach: UCLA
Pete Fiutak: UCLA
John Kennedy: Nebraska
Jackson Langendorf: Nebraska
Andrew Margolick: UCLA
Jake Margolick: Nebraska
Doug Millen: Nebraska
Johnny Rosenstein: UCLA
Joshua Schulman: Nebraska
Nick Shepkowski: UCLA
Clucko the Chicken: UCLA
CONSENSUS PICK: UCLA

San Diego State at Hawaii

Game Time: 11:00 PM ET
TV: MW
Consensus Line: San Diego State -6.5
– Game Preview & Prediction Coming

Big Game Ben: San Diego State*
E: San Diego State*
Nathan Erbach: Hawaii
Pete Fiutak: San Diego State
John Kennedy: San Diego State
Jackson Langendorf: Hawaii
Andrew Margolick: San Diego State
Jake Margolick: San Diego State
Doug Millen: San Diego State
Johnny Rosenstein: San Diego State
Joshua Schulman: San Diego State*
Nick Shepkowski: San Diego State*
Clucko the Chicken: San Diego State
CONSENSUS PICK: San Diego State

CFN College Football Expert Picks Results

Big Game Ben
Record: SU 131-41, ATS 88-83–1
E
Record: SU 123-49, ATS 84-87–1
Nathan Erbach
Record: SU 124-47, ATS 85-85–1
Pete Fiutak
Record: SU 137-35, ATS 86-85–1
John Kennedy
Record: SU 131-41, ATS 87-83–1
Jackson Langendorf
Record: SU 119-53, ATS 82-89–1
Andrew Margolick
Record: SU 129-43, ATS 85-86–1
Jake Margolick
Record: SU 128-44, ATS 86-85–1
Doug Millen
Record: SU 135-37, ATS 82-89–1
Johnny Rosenstein
Record: SU 140-32, ATS 94-77–1
Joshua Schulman
Record: SU 125-47, ATS 76-94–1
Nick Shepkowski
Record: SU 131-41, ATS 84-87–1
Clucko the Chicken
Record: SU 87-85, ATS 88-83–1
CONSENSUS PICK
Record: SU 122-50, ATS 88-83–1

Related: College Football Playoff Rankings Week 11: Reaction to All 25 Teams

This story was originally reported by College Football News on Nov 6, 2025, where it first appeared in the College Football section. Add College Football News as a Preferred Source by clicking here.

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