ESPN 'College GameDay' predictions for Week 5

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Week 5 of the 2026 college football season is here, and that means ESPN's "College GameDay" was back in full force to preview all of Saturday's action. With a ranked matchup in the Big Ten, they made the choice to head to Iowa City, Iowa, to watch the Ohio State Buckeyes play the Iowa Hawkeyes.

It is a massive game for both programs, with the Buckeyes looking to avoid a second loss and Iowa looking for a signature win after a 4-0 start to the season in thier quest to make their first ever appearance in the College Football Playoff. While Ohio State's loss was to the No. 1 team in the country, they can not afford another stumble with a brutal conference schedule awaiting them.

The usual crew of Rece Davis, Nick Saban, Kirk Herbstreit, Desmond Howard, and Pat McAfee were joined by guest picker Caitlin Clark to pick the top games of the weekend. She is from De Moines, Iowa, and is one of the best players in Iowa's history, being named an All-American all four years and the Big Ten Player of the Year three times before joining the WNBA.

Here is a look at all of their picks for the top games in Week 5 of the season, including the Alabama Crimson Tide vs. Mississippi State Bulldogs, Florida Gators vs. Missouri Tigers, and more

Alabama vs Mississippi State

  • Howard: Mississippi State
  • Saban: Alabama
  • McAfee: Alabama
  • Clark: Mississippi State
  • Herbstreit: Alabama

West Virginia vs Iowa State

  • Howard: Iowa State
  • Saban: West Virginia
  • McAfee: West Virginia
  • Clark: Iowa State
  • Herbstreit: West Virginia

Easter Michigan vs UMass

  • Howard: UMass
  • Saban: UMass
  • McAfee: UMass
  • Clark: UMass
  • Herbstreit: UMass

BYU vs TCU

  • Howard: BYU
  • Saban: BYU
  • McAfee: BYU
  • Clark: BYU
  • Herbstreit: BYU

Cincinnati vs Arizona

  • Howard: Arizona
  • Saban: Arizona
  • McAfee: Cincinnati
  • Clark: Arizona
  • Herbstreit: Cincinnati

Miami vs Clemson

  • Howard: Miami
  • Saban: Miami
  • McAfee: Miami
  • Clark: Miami

Washington vs USC

  • Howard: USC
  • Saban: USC
  • McAfee: USC
  • Clark: USC
  • Herbstreit: Washington

Michigan vs Minnesota

  • Howard: Michigan
  • Saban: Michigan
  • McAfee: Michigan
  • Clark: Michigan
  • Herbstreit: Minnesota

Florida vs Missouri

  • Howard: Florida
  • Saban: Florida
  • McAfee: Florida
  • Clark: Florida
  • Herbstreit: Florida

Ohio State Buckeyes vs. Iowa Hawkeyes

  • Howard: Iowa
  • Saban: Ohio State
  • McAfee: Ohio State
  • Clark: Iowa
  • Herbstreit: Ohio State

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This article originally appeared on FSU Wire: ESPN 'College GameDay' predictions for Week 5

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