Notre Dame vs Syracuse Prediction: Can the Irish Make a CFP Statement?
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Syracuse has pulled off something amazing before.
Last year, Miami had the ACC Championship and a College Football Playoff spot all to itself, and all it had to do was beat Syracuse in the regular season finale.
Cam Ward and company lost 42-38, and that was it. The Orange pulled it off, but …
That team won ten games. This Syracuse team has lost six straight games, it’s out of the bowl picture, and its home finale is against Boston College next week.
Notre Dame is currently comfortable in the CFP rankings at the 9. However, this could change fast if there are a slew of big upsets in the top conferences, and against a bad Orange team, nothing less than a total wipeout would do.
Notre Dame vs Syracuse Preview
How To Watch Notre Dame vs Syracuse
Date: Saturday, November 22, 2025
Game Time: 3:30 PM ET
TV: NBC
Location: Memorial Stadium, Clemson, SC
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Why Syracuse Will Win
This was supposed to be when former Notre Dame quarterback Steve Angeli was going to make his return to South Bend, fire away on his former team, and …
He’s been out for a few months with a season-ending injury. Syracuse will likely play around with its quarterbacks a bit to throw a few different curveballs at the Irish defense.
It might have lost to Georgia Tech badly, but it threw for big yards and at least made it interesting for about 35 minutes. It has to use whatever quarterback that gets out there to keep on firing and put the pressure on the Irish secondary. However …
Why Notre Dame Will Win
Will enough people be watching this for Jeremiyah Love to make a seriously big Heisman statement?
In a year when there aren’t any real candidates, Love has been among the best players in America, and now he and Jadarian Price should run as much as they want to.
CJ Carr has been fantastic this season – two picks against Pitt aside – but the ground game and defense owned the game.
The Syracuse defensive front was able to hold up shockingly well against the Miami offensive front and the running game, but it was gashed for over 200 yards by teams able to commit to the run over the last several weeks.
The Irish aren’t going to mess around. As long as they remember to run, and do it at least 35 times, they should be able to crank out big play after big play, there’s no Syracuse pass rush to be a bother as Carr goes off, and …
Notre Dame vs Syracuse Prediction, Betting Lines
Notre Dame seems way overdue for its Northern Illinois moment, but Syracuse doesn’t have the offense or the chops to pull this off. The Irish are rolling too well.
There will be a few hiccups early, but once the snowball gets rolling, the avalanche of Fighting Irish points will come.
Notre Dame 44, Syracuse 10
Line: Notre Dame -36.5, o/u: 50.5
ATS Confidence out of 5: 3
Must See Rating: 2.5
Consensus Line from BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.
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Related: Miami vs Virginia Tech Prediction: The Hurricanes Had Better Be Fantastic
This story was originally reported by College Football News on Nov 22, 2025, where it first appeared in the College Football section. Add College Football News as a Preferred Source by clicking here.
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