USC vs Louisiana Prediction: Another Chance For the Trojans To Shine
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USC is playing like a team that’s had enough.
It’s USC. It’s supposed to be a player in the College Football Playoff chase, and last week against Fresno State, it put up a 39-0 performance that showed that it’s locked in and ready to be special.
Louisiana is a good team with plenty of potential to be a fighter in the Sun Belt. It didn’t play all that well last week, but it still beat Lamar 38-7.
USC vs Louisiana: Quick Hits
- It’s the first time the two schools have ever played. USC beat Georgia State from the Sun Belt last year 59-20. Louisiana last played a Big Ten team in 2023, losing to Minnesota 35-24.
- USC starts the Big Ten season at Rutgers next week, and then come the home showdowns against Oregon and Washington.
- Louisiana gets UAB next week – the Sun Belt season starts the first weekend of October against Arkansas State.
How To Watch USC vs Louisiana
Date: Saturday, September 12, 2026
Game Time: 11:00 PM ET
TV: BTN
Location: Los Angeles Memorial Coliseum, Los Angeles, CA
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Why Louisiana Will Win
Quarterback Lunch Winfield has to keep firing away. He threw two picks against Lamar, but he was able to keep things moving with the midrange passing game, and his legs. Dangerous on the move, he and running back Darrell Smith each ran for 84 yards.
Granted, it was mostly against the backups, but San Jose State got hot late in the opener against USC by dinking and dunking its way down the field. Winfield has to do that from the start.
Why USC Will Win
What’s working so well over the first two games? The run defense has been a rock, and the offense is getting a Heisman-caliber start out of quarterback Jayden Maiava. All he has done is hit 89% of his passes for 635 yards and five scores. He’s taking target practice.
USC isn’t making the big mistakes the Ragin’ Cajuns will need to make this a fight.
USC vs Louisiana Prediction, Betting Lines
Can USC be as focused and sharp as it was against Fresno State? Maybe not, and it still won’t matter.
The Louisiana defensive front will bring a little bit of pressure, but the offense will struggle to close out decent drives with points. It’ll be another day for the Trojans to show off.
USC 47, Louisiana 13
Latest Consensus Line: USC -31.5, o/u: 59.5
ATS Confidence (out of 5): 3.5
Must See Rating (out of 5): 2
Consensus line based on BetMGM, Caesars, DraftKings, and FanDuel. Game odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.
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