College Football Week 12 Expert Picks for the 16 Biggest Games

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College Football Week 12 Expert Picks for the 16 Biggest Games

Now it gets really serious.

Last week it was more about the big games in the Big Ten – Indiana survived its date with Penn State, Iowa and Oregon put on a classic, and Washington got knocked out by Washington – but this week, the SEC takes center stage.

Texas A&M takes on South Carolina, Oklahoma vs Alabama will be massive, Ole Miss has to sidestep Florida, and Texas at Georgia will be a whale of a primetime battle.

The CFN experts pick those four, and Clemson at Louisville, Minnesota at Oregon, Wisconsin at Indiana, Notre Dame at Pitt, Michigan at Northwestern, Virginia at Duke, UCF at Texas Tech, NC State at Miami, Iowa at USC, UCLA at Ohio State, TCU at BYU, and with Saturday night closing out with the Mountain West showdown between Boise State and San Diego State.

Expert Predictions for Texas at Georgia and All the Top Week 12 Matchups

Sep 27, 2025; Athens, Georgia, USA; Georgia Bulldogs quarterback Gunner Stockton (14) passes against the Alabama Crimson Tide in the first half at Sanford Stadium.© Brett Davis-Imagn Images

Clemson at Louisville

Game Time: 7:30 PM ET
TV: ESPN
Consensus Line: Louisville -3
– Game Preview & Prediction Coming

Big Game Ben: Louisville
E: Clemson
Nathan Erbach: Louisville
Pete Fiutak: Louisville
John Kennedy: Louisville
Jackson Langendorf: Clemson
Andrew Margolick: Louisville
Jake Margolick: Louisville
Doug Millen: Louisville
Johnny Rosenstein: Louisville
Joshua Schulman: Clemson
Nick Shepkowski: Louisville
Clucko the Chicken: Clemson
CONSENSUS PICK: Louisville

Minnesota at Oregon

Game Time: 9:00 PM ET
TV: FOX
Consensus Line: Oregon -25.5
– Game Preview & Prediction Coming

Big Game Ben: Oregon
E: Oregon*
Nathan Erbach: Oregon*
Pete Fiutak: Oregon*
John Kennedy: Oregon
Jackson Langendorf: Oregon
Andrew Margolick: Oregon*
Jake Margolick: Oregon*
Doug Millen: Oregon
Johnny Rosenstein: Oregon*
Joshua Schulman: Oregon*
Nick Shepkowski: Oregon
Clucko the Chicken: Oregon
CONSENSUS PICK: Oregon*

Wisconsin at Indiana

Game Time: 12:00 PM ET
TV: BTN
Consensus Line: Indiana -29.5
– Game Preview & Prediction Coming

Big Game Ben: Indiana
E: Indiana
Nathan Erbach: Indiana*
Pete Fiutak: Indiana
John Kennedy: Indiana
Jackson Langendorf: Indiana*
Andrew Margolick: Indiana*
Jake Margolick: Indiana*
Doug Millen: Indiana
Johnny Rosenstein: Indiana*
Joshua Schulman: Indiana
Nick Shepkowski: Indiana
Clucko the Chicken: Indiana
CONSENSUS PICK: Indiana*

South Carolina at Texas A&M

Oct 19, 2024; Norman, Oklahoma, USA; South Carolina Gamecocks quarterback LaNorris Sellers (16) warms up before the game against the Oklahoma Sooners at Gaylord Family-Oklahoma Memorial Stadium© Kevin Jairaj-Imagn Images

Game Time: 12:00 PM ET
TV: ESPN
Consensus Line: Texas A&M -19.5
– Game Preview & Prediction

Big Game Ben: Texas A&M*
E: Texas A&M
Nathan Erbach: Texas A&M*
Pete Fiutak: Texas A&M
John Kennedy: Texas A&M*
Jackson Langendorf: Texas A&M*
Andrew Margolick: Texas A&M
Jake Margolick: Texas A&M
Doug Millen: Texas A&M*
Johnny Rosenstein: Texas A&M*
Joshua Schulman: Texas A&M
Nick Shepkowski: Texas A&M*
Clucko the Chicken: South Carolina
CONSENSUS PICK: Texas A&M*

Notre Dame at Pitt

Game Time: 12:00 PM ET
TV: ABC
Consensus Line: Notre Dame -12.5
– Game Preview & Prediction Coming

Big Game Ben: Notre Dame
E: Notre Dame
Nathan Erbach: Notre Dame
Pete Fiutak: Notre Dame*
John Kennedy: Notre Dame
Jackson Langendorf: Notre Dame
Andrew Margolick: Notre Dame*
Jake Margolick: Notre Dame
Doug Millen: Notre Dame*
Johnny Rosenstein: Notre Dame*
Joshua Schulman: Notre Dame*
Nick Shepkowski: Notre Dame
Clucko the Chicken: Pitt
CONSENSUS PICK: Notre Dame

Michigan at Northwestern

Game Time: 12:00 PM ET
TV: FOX
Consensus Line: Michigan -12.5
– Game Preview & Prediction Coming

Big Game Ben: Michigan*
E: Michigan
Nathan Erbach: Michigan
Pete Fiutak: Michigan*
John Kennedy: Michigan
Jackson Langendorf: Michigan*
Andrew Margolick: Michigan*
Jake Margolick: Michigan
Doug Millen: Michigan
Johnny Rosenstein: Michigan*
Joshua Schulman: Michigan*
Nick Shepkowski: Michigan
Clucko the Chicken: Michigan
CONSENSUS PICK: Michigan

Oklahoma at Alabama

Game Time: 3:30 PM ET
TV: ABC
Consensus Line: Alabama -6
– Game Preview & Prediction

Big Game Ben: Alabama*
E: Alabama
Nathan Erbach: Alabama
Pete Fiutak: Alabama
John Kennedy: Alabama
Jackson Langendorf: Alabama
Andrew Margolick: Alabama
Jake Margolick: Alabama
Doug Millen: Alabama
Johnny Rosenstein: Alabama
Joshua Schulman: Alabama
Nick Shepkowski: Alabama
Clucko the Chicken: Oklahoma
CONSENSUS PICK: Alabama

Virginia at Duke

Game Time: 3:30 PM ET
TV: ESPN2
Consensus Line: Duke -4
– Game Preview & Prediction Coming

Big Game Ben: Virginia
E: Duke
Nathan Erbach: Duke
Pete Fiutak: Duke
John Kennedy: Virginia
Jackson Langendorf: Duke
Andrew Margolick: Virginia
Jake Margolick: Virginia
Doug Millen: Duke*
Johnny Rosenstein: Duke*
Joshua Schulman: Duke
Nick Shepkowski: Duke
Clucko the Chicken: Duke
CONSENSUS PICK: Duke*

UCF at Texas Tech

Game Time: 3:30 PM ET
TV: FOX
Consensus Line: Texas Tech -23.5
– Game Preview & Prediction Coming

Big Game Ben: Texas Tech
E: Texas Tech
Nathan Erbach: Texas Tech
Pete Fiutak: Texas Tech
John Kennedy: Texas Tech
Jackson Langendorf: Texas Tech
Andrew Margolick: Texas Tech
Jake Margolick: Texas Tech
Doug Millen: Texas Tech
Johnny Rosenstein: Texas Tech
Joshua Schulman: Texas Tech
Nick Shepkowski: Texas Tech
Clucko the Chicken: UCF
CONSENSUS PICK: Texas Tech

NC State at Miami

Sep 20, 2025; Miami Gardens, Florida, USA; Miami Hurricanes head coach Mario Cristobal reacts after the game against the Florida Gators at Hard Rock Stadium. © Sam Navarro-Imagn Images

Game Time: 3:30 PM ET
TV: ABC
Consensus Line: Miami -14.5
– Game Preview & Prediction Coming

Big Game Ben: Miami
E: Miami
Nathan Erbach: Miami*
Pete Fiutak: Miami
John Kennedy: NC State
Jackson Langendorf: Miami
Andrew Margolick: Miami
Jake Margolick: Miami*
Doug Millen: Miami
Johnny Rosenstein: Miami
Joshua Schulman: Miami*
Nick Shepkowski: Miami
Clucko the Chicken: Miami
CONSENSUS PICK: Miami

Iowa at USC

Game Time: 3:30 PM ET
TV: BTN
Consensus Line: USC -6.5
– Game Preview & Prediction Coming

Big Game Ben: USC
E: USC
Nathan Erbach: USC
Pete Fiutak: USC
John Kennedy: USC
Jackson Langendorf: USC*
Andrew Margolick: USC
Jake Margolick: USC
Doug Millen: USC
Johnny Rosenstein: USC
Joshua Schulman: USC
Nick Shepkowski: USC
Clucko the Chicken: Iowa
CONSENSUS PICK: USC

Florida at Ole Miss

Game Time: 7:00 PM ET
TV: ESPN
Consensus Line: Ole Miss -14.5
– Game Preview & Prediction

Big Game Ben: Ole Miss*
E: Ole Miss*
Nathan Erbach: Ole Miss*
Pete Fiutak: Ole Miss
John Kennedy: Ole Miss*
Jackson Langendorf: Ole Miss*
Andrew Margolick: Ole Miss*
Jake Margolick: Ole Miss*
Doug Millen: Ole Miss
Johnny Rosenstein: Ole Miss*
Joshua Schulman: Ole Miss*
Nick Shepkowski: Ole Miss
Clucko the Chicken: Florida
CONSENSUS PICK: Ole Miss*

UCLA at Ohio State

Game Time: 7:30 PM ET
TV: NBC
Consensus Line: Ohio State -32.5
– Game Preview & Prediction Coming

Big Game Ben: Ohio State*
E: Ohio State
Nathan Erbach: Ohio State
Pete Fiutak: Ohio State*
John Kennedy: Ohio State
Jackson Langendorf: Ohio State
Andrew Margolick: Ohio State*
Jake Margolick: Ohio State
Doug Millen: Ohio State
Johnny Rosenstein: Ohio State*
Joshua Schulman: Ohio State
Nick Shepkowski: Ohio State
Clucko the Chicken: UCLA
CONSENSUS PICK: Ohio State

Texas at Georgia

Game Time: 7:30 PM ET
TV: ABC
Consensus Line: Georgia -6
– Game Preview & Prediction Coming

Big Game Ben: Georgia
E: Georgia
Nathan Erbach: Georgia
Pete Fiutak: Georgia
John Kennedy: Georgia
Jackson Langendorf: Georgia*
Andrew Margolick: Georgia
Jake Margolick: Georgia*
Doug Millen: Georgia
Johnny Rosenstein: Georgia*
Joshua Schulman: Georgia
Nick Shepkowski: Georgia
Clucko the Chicken: Texas
CONSENSUS PICK: Georgia

TCU at BYU

Oct 18, 2025; Fort Worth, Texas, USA; TCU Horned Frogs tight end Ka’Morreun Pimpton (88) reacts with offensive lineman Cooper Powers (77) and tight end Chase Curtis (81) after scoring a touchdown against the Baylor Bears during the second half of a game at Amon G. Carter Stadium. © Raymond Carlin III-Imagn Images

Game Time: 10:15 PM ET
TV: ESPN
Consensus Line: BYU -4.5
– Game Preview & Prediction Coming

Big Game Ben: BYU
E: BYU
Nathan Erbach: BYU
Pete Fiutak: BYU
John Kennedy: BYU
Jackson Langendorf: BYU
Andrew Margolick: BYU
Jake Margolick: BYU
Doug Millen: BYU
Johnny Rosenstein: BYU*
Joshua Schulman: BYU
Nick Shepkowski: BYU
Clucko the Chicken: BYU
CONSENSUS PICK: BYU

Boise State at San Diego State

Game Time: 10:30 PM ET
TV: CBS Sports Network
Consensus Line: San Diego State -2.5
– Game Preview & Prediction Coming

Big Game Ben: Boise State
E: Boise State
Nathan Erbach: SDSU
Pete Fiutak: SDSU
John Kennedy: Boise State
Jackson Langendorf: SDSU
Andrew Margolick: SDSU
Jake Margolick: Boise State
Doug Millen: SDSU
Johnny Rosenstein: Boise State
Joshua Schulman: Boise State
Nick Shepkowski: SDSU
Clucko the Chicken: Boise State
CONSENSUS PICK: Boise State

Results So Far

Big Game Ben
Record: SU 144-44, ATS 94-93–1
E
Record: SU 135-53, ATS 92-95–1
Nathan Erbach
Record: SU 138-49, ATS 96-90–1
Pete Fiutak
Record: SU 148-40, ATS 94-93–1
John Kennedy
Record: SU 144-44, ATS 96-90–1
Jackson Langendorf
Record: SU 132-56, ATS 91-96–1
Andrew Margolick
Record: SU 139-49, ATS 93-94–1
Jake Margolick
Record: SU 141-47, ATS 96-91–1
Doug Millen
Record: SU 147-41, ATS 88-99–1
Johnny Rosenstein
Record: SU 152-36, ATS 103-84–1
Joshua Schulman
Record: SU 138-50, ATS 83-103–1
Nick Shepkowski
Record: SU 142-46, ATS 91-96–1
Clucko the Chicken
Record: SU 92-96, ATS 93-94–1
CONSENSUS PICK
Record: SU 134-54 ATS 97-90–1 

This story was originally reported by College Football News on Nov 13, 2025, where it first appeared in the College Football section. Add College Football News as a Preferred Source by clicking here.

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